센터소개
About Us

유전단백체연구센터는 유전단백체학(Proteogenomics)에 기반한 정밀의료(Precision Medicine) 실현을 추구하고 있습니다...
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센터멤버
Members

유전단백체연구센터 멤버를 소개합니다
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센터시설
Facilities

유기적 공동연구를 통한 유전단백체연구센터의 운영은 이렇게 이루어 집니다. 개별 연구자들의 다양한 단백체 연구 수요에...
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연구현황 | Research

Proteogenomic Characterization of Human Early-Onset Gastric Cancer

Mun, D.-G.; Bhin, J.; Kim, S.; Kim, H.; Jung, J. H.; Jung, Y.; Jang, Y. E.; Park, J. M.; Kim, H.; Jung, Y.; Lee, H.; Bae, J.; Back, S.; Kim, S.-J.; Kim, J.; Park, H.; Li, H.; Hwang, K.-B.; Park, Y. S.; Yook, J. H.; Kim, B. S.; Kwon, S. Y.; Ryu, S. W.; Park, D. Y.; Jeon, T. Y.; Kim, D. H.; Lee, J.-H.; Han, S.-U.; Song, K. S.; Park, D.; Park, J. W.; Rodriguez, H.; Kim, J. Lee, H.; Kim, K. P.; Yang, E. G.; Kim, H. K.; Paek, E.; Lee, S.; Lee, S.-W.; Hwang, D. Cancer Cell 2019, 35, 111-124.

We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation ...

Publication List

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"Blockers of Wnt3a, Wnt10a, or β-Catenin Prevent Chemotherapy-Induced Neuropathic Pain in Vivo Neurotherapeutics" Kim H.K.; Bae J.; Lee S.H.; Hwang S.-H.; Kim M.-S; Kim M.J.; Jun S.; Cervantes C.L.; Jung Y.-S.; Back S.; Lee H.; Lee S.-E.; Dougherty P.; Lee S.-W.; Park J.-I.; Abdi S.; Neurotherapeutics 2020, in press

> in press

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"PASS-DIA: A data-independent acquisition approach for discovery studies"   Mun D.-G.; Renuse S.; Saraswat M.; Madugund A.; Udainiya S.; Kim H.; Park S.-K.R.; Zhao H.; Nirujogi R.S.; Na C.H.; Kannan N.;Yates J.R.III.; Lee S.-W.; Pandey A.; Analytical Chemistry 2020, in press

> in press

센터소식 | News

"전주기적 유전단백체연구 허브 조성... 국가 정밀의료연구 중추적 역할 수행"

대한화학회: 화학세계 E-Book 2019년 12월호
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"ICPC Korea University Team Proteogenomically Characterizes Early-Onset Gastric Cancer"

National Cancer Institute (NIH), Center for Strategic Initiatives
Wednesday, January 16, 2019
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