센터소개
About Us

유전단백체연구센터는 유전단백체학(Proteogenomics)에 기반한 정밀의료(Precision Medicine) 실현을 추구하고 있습니다...
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센터멤버
Members

유전단백체연구센터 멤버를 소개합니다
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센터시설
Facilities

유기적 공동연구를 통한 유전단백체연구센터의 운영은 이렇게 이루어 집니다. 개별 연구자들의 다양한 단백체 연구 수요에...
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연구현황 | Research

Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes

Hyeon D.Y.; Nam D.; Han Y.; Kim D.K.; Kim G.; Kim D.; Bae J.; Back S.; Mun D.-G.; Madar I.H.; Lee H.; Kim S.-J.; Kim H.; Hyun S.; Kim C.R.; Choi S.A.; Kim Y.R.; Jeong J.; Jeon S.; Choo Y.W.; Lee K.B.; Kwon W.; Choi S.; Goo T.; Park T.; Suh Y.-A.; Kim H.; Ku J.-L.; Kim M.-S.; Paek E.; Park D.; Jung K.; Baek S.H.; Jang J.-Y, Hwang D.; Lee S.-W.; Nature Cancer, 4, 290-307, 2023

We report a proteogenomic analysis of pancreatic ductal adenocarcinoma (PDAC). Mutation–phosphorylation correlations identified signaling pathways associated with somatic mutations in significantly mutated genes. Messenger RNA–protein abundance correlations revealed potential prognostic biomarkers correlated with patient survival. Integrated clustering of mRNA, protein and phosphorylation data identified six PDAC subtypes. Cellular pathways represented by mRNA and protein signatures, defining the subtypes and compositions of cell types in the subtypes, characterized them as classical p rogenitor (TS1), squamous (TS2–4), immunogenic progenitor (IS1) and exocrine-like (IS2) subtypes. Compared with the mRNA data, protein and phosphorylation data further classified the squamous subtypes into activated stroma-enriched (TS2), invasive (TS3) and invasive-proliferative (TS4) squamous subtypes. ...

Publication List

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"Synthesis of Carbamidomethyl Cysteine and its Use for Quantification of Cysteinyl Peptides by Targeted Proteomics" Yeom, S.; Nam, D.; Bok, K. H.; Kwon, H. K.; Kim, S.; Lee, S.-W.; Kim, H. J. Anal. Chem. 2023, 95 (38), 14413-14420.
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"Targeted proteomics data interpretation with DeepMRM" Park, J.; Wilkins, C.; Avtonomov, D.; Hong, J.; Back, S.; Kim, H.; Shulman, N.; MacLean, B.X.; Lee, S.-W.; Kim, S.; Cell Reports Methods. 2023, 3 (7), 2667-2375.

센터소식 | News

"병역특례 연구원(박사과정) 모집"

유전단백체연구센터
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"[기고] 항암치료 개선할 수 있는 정밀의료 시스템 도입해야"

한국경제
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